Tehran University of Medical Sciences (TUMS) Academic Journal of Surgery 2423-3218 4 3 2017 12 29 82 86 Maria Ajdari Department of Surgery, School of Medicine AND Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Reza Saidi Department of Surgery, School of Medicine AND Research Center for Improvement of Surgical Outcomes and Procedures, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Mehdi Jafari Department of Surgery, School of Medicine AND Research Center for Improvement of Surgical Outcomes and Procedures, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Abolfazl Shojaiefard Department of Surgery, School of Medicine AND Research Center for Improvement of Surgical Outcomes and Procedures, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Shirzad Nasiri Department of Surgery, School of Medicine AND Research Center for Improvement of Surgical Outcomes and Procedures, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Ali Mir Department of Surgery, School of Medicine AND Research Center for Improvement of Surgical Outcomes and Procedures, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Ahmadreza Soroush Department of Surgery, School of Medicine AND Research Center for Improvement of Surgical Outcomes and Procedures, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran 2017 12 29 Pancreas transplantation has emerged as an effective treatment for patients with diabetes mellitus, especially those with established end-stage renal disease. Surgical and immunosuppressive advances have significantly improved allograft survival. The procedure reduces mortality compared with diabetic kidney transplant recipients and waitlisted patients. Improvements in diabetic nephropathy and retinopathy have also been demonstrated. Pancreas transplantation can improve cardiovascular risk profiles, improve cardiac function, and decrease cardiovascular events. Finally, improvements in diabetic neuropathy and quality of life can result from pancreas transplantation. Pancreas transplantation remains the most effective method to establish durable euglycemia for patients with diabetes mellitus. https://ajs.tums.ac.ir/index.php/ajs/article/view/128 https://ajs.tums.ac.ir/index.php/ajs/article/download/128/75