Tehran University of Medical Sciences (TUMS) Academic Journal of Surgery 2423-3218 7 2 2024 07 01 47 51 nima mohammadiafrakoti anesthesia fellowship mohammdsadegh talebi kahdouei Medical school, Tehran University of Medical science, Tehran, Iran alireza khajehnasiri Anesthesiology Department, Tehran University of Medical Sciences, Tehran, Iran arash heroababdi Anesthesiology Department, Tehran University of Medical Sciences, Tehran, Iran samaneh haji mollarabei Neurology Department, Alborz University of Medical Sciences, Alborz, Iran fatemeh aghaei Medical school, Tehran University of Medical science, Tehran, Iran 2024 06 16 Objective: The aim of this study is to investigate the relation between LDH and CRP levels and mortality of COVID-19 (SARS-CoV-2) patients admitted in SURGERY ICU at Shariati Hospital from 19 February 2020 till 19 February 2021 Methods: Our study is a cross-sectional descriptive study . There are 81 patients that are enrolled in this study. We studied the lab reports including CBC parameters (WBC, neutrophils count, neutrophil percentage ) other inflammatory markers ESR and CRP and we also study the medical records of cases for collecting the details about age, gender , length of stay in SURGERY ICU, BMI, fever, survival status, comorbidity, intubation and NIV that was referred to Shariati hospital Tehran from  19 February 2020 (30-11-1398) till 19 February 2021(1-12-1399) regarding the relation between LDH and CRP levels and mortality of COVID-19 (SARS-CoV-2) patients admitted in SURGERY ICU. The data obtained was analyzed by the SPSS software and the significance value of < 0.05 was considered. Result: In this study, the information of 81 patients was considered. The data comes from medical records of Shariati hospital, Tehran. We took 11 variables to compare data of different patients that were recorded in registry and system of medical records in Shariati hospital, Tehran. This study population included 81 patients, out of which 41 were female patients and 40 were male patients from age 25 to 89. In total 80.2% had mild disease vs 18.5% who had severe disease . 65 patients survived and 16 were admitted to the SURGERY ICU with endotracheal intubation and later on died. The length of stay in SURGERY ICU is 1-25 days. Out of 81 patients 52 (62.4%)have comorbidity and 29 (35.8%) don't have comorbidity. 12 patients (14.8%) receive NIV and 69 patients (85.2%) don't receive NIV. Most of the patients don't have fever. The minimum and maximum level of CRP are 4 and 416 respectively and for LDH are 9 and 2401 respectively. The prognostic factors for the severity of COVID-19 infection identified in this study (CRP and LDH) help predict the course of the disease at an early stage. Elevated concentrations of CRP and LDH at admission were found to be associated with a higher risk for COVID-19 severity as they are significant (p-value =0.049 and 0.048 respectively). Conclusion: In this study laboratory investigation showed the SURGERY ICU patients to be having significantly higher values of inflammatory markers CRP and LDH than the non-SURGERY ICU patients. LDH and CRP were superior and an effective biomarker in predicting the severity of COVID-19. https://ajs.tums.ac.ir/index.php/ajs/article/view/264