Tehran University of Medical Sciences (TUMS) Academic Journal of Surgery 2423-3218 8 1 2025 04 25 22 28 Fezzeh Elyasinia Associate Professor of Laparoscopic Surgery, Advanced Minimally Invasive Surgery Fellowship, Department of General Surgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Ahmadreza Soroush Professor of Surgery, Department of General Surgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Khosrow Najjari Associate Professor of Laparoscopic Surgery, Advanced Minimally Invasive Surgery Fellowship, Department of General Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran Mohammad Talebpour Professor of Surgery, Department of General Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran Amir Mohammad Barani Medical Student, Student Research Committee, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran Reza Eslamian Division of Thoracic Surgery, Department of Surgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Hossein Zabihi-Mahmoudabadi 6 Associate Professor of General Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran Morteza Ahmadinasab Assistant Professor of Surgery, Advanced Minimally Invasive Surgery Fellowship, Department of General Surgery, Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran 2024 11 29 Background: Laparoscopic cholecystectomy is a surgical procedure used to remove the gallbladder in patients experiencing gallstones or acute cholecystitis. Pain is a common side effect of surgery. Objective: This study evaluates the effectiveness of intraperitoneal dexamethasone injection from the umbilical port site in alleviating pain after laparoscopic cholecystectomy. Methods: This research followed a triple-blind clinical trial that included 80 randomly selected patients who were hospitalized at Shahid Mohammadi Hospital in Bandar Abbas and deemed eligible for laparoscopic cholecystectomy. Patients were randomly divided into two groups, each containing 40 participants. In the test group, 8 mg of dexamethasone was injected into the intraperitoneal space through the umbilical port site during surgery, while no drug was administered in the control group. Pain scores were measured postoperatively using the VAS questionnaire at 6, 12, and 18 hours after surgery. The collected data were analyzed using SPSS version 21 statistical software, employing independent t-tests and chi-square tests. Results: The experimental group exhibited significantly lower levels of nausea, vomiting, analgesic consumption, and pain compared to the control group (p<0.000). Conclusions: Study confirmed that intraperitoneal dexamethasone infusion from the port site significantly reduced postoperative pain, nausea, vomiting, and the consumption of painkillers. https://ajs.tums.ac.ir/index.php/ajs/article/view/290