Tehran University of Medical Sciences (TUMS) Academic Journal of Surgery 2423-3218 8 2 2025 08 24 53 60 Mahdi Mohsenzadeh MD, Clinical Research Development unit, Bohlool hospital, Gonabad University of medical Sciences, Gonabad, Iran Majid Zamani Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran AliMohammad Mokhtari Department of Epidemiology and Biostatistics, School of Health, Social Development and Health Promotion Research Center, Gonabad University of Medical Sciences, Gonabad, Iran Alireza Talaie MSc in Nursing, Faculty member of Operating Room, Department of Operating Room, School of Paramedical Sciences, Gonabad University of Medical Sciences, Gonabad, Iran Fatemeh Pouladkhay Gonabad University of Medical Sciences 2025 03 24 Background: The COVID-19 pandemic has introduced challenges in medical practices, impacting laboratory testing and raising concerns about the reliability of specific tests. This study aimed to assess the reliability of using hematology test results to delay surgeries, particularly in spinal interventions. Methods: A retrospective analysis was conducted on the medical records of 220 patients who had undergone spinal surgery between October 2021 and June 2023, and whose COVID-19 status was documented. Inclusion criteria encompassed individuals without a history of blood disorders, pregnancy, drug or smoking addiction, or recent surgical procedures. Data analysis utilized SPSS software, employing descriptive methods and statistical tests such as the independent samples t-test and chi-square test, with statistical significance set at p < 0.05. Results: Among the analyzed patients, 56.4% were male. Fusion surgery was performed on 82.7% of individuals, while laminectomy surgery was performed on 17.3%. Approximately 65.9% had no underlying conditions, and 67.3% had a history of prior COVID-19 infection. Postoperative thrombotic complications were observed in 2.2%. Comparisons between patients with and without coagulation complications revealed no significant differences in demographic information, history of COVID-19 infection, or coagulation test results. Furthermore, a comparison of D-dimer test outcomes between individuals with normal D-dimer levels [54 people] and those with levels exceeding 500 [55 people] demonstrated no significant distinction (p > 0.05). Conclusions: Based on the findings, this study concludes that, for major and extensive spinal surgeries in patients with a history of COVID-19, evaluating D-dimer test results does not offer significant assistance in decision-making. https://ajs.tums.ac.ir/index.php/ajs/article/view/309