Tehran University of Medical Sciences (TUMS) Academic Journal of Surgery 2423-3218 8 2 2025 08 24 70 74 Kourosh Mohammadi Mazleghani Faculty of Medicine, Iran University of Medical Sciences and Health Services, Tehran, Iran Majid Rezaei Tavirani Faculty of Medicine, Iran University of Medical Sciences and Health Services, Tehran, Iran Alireza Nagehi Faculty of Medicine, Iran University of Medical Sciences and Health Services, Tehran, Iran Mostafa Dahmardehei Professor, Department of Reconstructive Plastic Surgery, Iran University of Medical Sciences, Motahari Hospital, Burn Research Center, Tehran, Iran Mostafa Rezaei Tavirani Professor, Department of Reconstructive Plastic Surgery, Iran University of Medical Sciences, Motahari Hospital, Burn Research Center, Tehran, Iran 2025 05 16 Background: One of the primary concerns among burn patients with third-degree skin injuries is the healing process and the severity of resulting skin lesions—an issue that has attracted considerable research attention. Accordingly, the present study aimed to evaluate the therapeutic effects of biocompatible wound dressings and skin grafting on the healing of third-degree traumatic burn wounds in patients admitted to Motahari Hospital. Methods: This semi-experimental randomized clinical trial was conducted in 2024. The study population included 18 patients with third-degree traumatic burns covering less than 5 cm², referred to the Motahari Burn Center in Tehran. Data were collected using a researcher-designed form. Statistical analyses were performed using SPSS software, employing the Mann–Whitney and Spearman tests. Results: The mean age of participants was 36.25 years, and most were male (77.77%). The leading cause of burns was gas exposure (44.43%), and 66.68% of patients had burns covering 25% to 45% of total body surface area. Patients treated with biocompatible wound dressings experienced significantly less scar formation, improved follicle and dermal appendage restoration, and more aesthetically favorable skin regeneration. Conclusions: Addressing patients' concerns about wound healing is essential, and effective therapeutic approaches should be employed. Based on the study's findings, the use of biocompatible wound dressings is recommended in skin and burn recovery services. https://ajs.tums.ac.ir/index.php/ajs/article/view/315