Tehran University of Medical Sciences (TUMS) Academic Journal of Surgery 2423-3218 8 4 2025 12 31 137 145 Seyed Mojtaba Marashi Dr Ali Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Kamyar Dabir Ashrafi Dr Ali Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Samaneh Hajy Molla Rabi Department of Neurology, Dr Rajaee Hospital, Alborz University, Alborz, Iran Mohammad Ali Haji Azizi Dr Ali Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Nima Mohammadi Afrakoti Dr Ali Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran 2025 12 17 Sepsis is known as a leading cause of morbidity, mortality, and healthcare burdened all around the globe, with  imited targeted therapies beyond standard supportive care. Currently, management strategies focus mostly on controlling the infection and hemodynamic stabilization but often fail to address to pathophysiological processes of inflammation, oxidative stress, and microvascular injury. Vitamin C (ascorbic acid) is a potential antioxidant and immunomodulator, and has gained attention as an adjunctive therapy due to its role in reducing oxidative damage, inflammatory responses regulation, and supporting catecholamine synthesis. In addition, the synergistic combination of vitamin C and thiamine has been proposed to enhance cellular metabolism and organ protection in patients who are critically ill. In this study, we investigated the effects of  itamin C, both alone and combination with thiamine, on clinical outcomes and biochemical markers in patients with sepsis. Our findings provide new insights into the potential role of vitamin supplementation in modulating disease progression and improving prognosis, highlighting its possible integration into sepsis management strategies. https://ajs.tums.ac.ir/index.php/ajs/article/view/336