Academic Journal of Surgery 2015. 2(1-2):18-22.

Effect of Systemic Granisetron in the Clinical Course of Spinal Anesthesia with Hyperbaric Bupivacaine for Outpatient Cystoscopy
Sussan Soltani-Mohammadi, Salimeh Esmaeili, Alireza Saliminia


Background: The goals of this study are evaluation the effect of intravenous (IV) granisetron on the duration of sensory and motor block produced by intrathecal hyperbaric bupivacaine and also post-operative nausea and vomiting in patients undergoing outpatient cystoscopy.
Methods: 62 patients, undergoing cystoscopy received either 3 mg IV granisetron or placebo 15 minutes before the spinal block. Sensory and motor block were assessed after the intrathecal injection of bupivacaine
every 2 minutes until the maximum block was achieved and thereafter every 15 minutes until recovery from the sensory and motor block.
Results: Demographic data were not statistically different in the study groups. Duration of sensory and motor block were also not statistically different between the study groups (P = 0.060 and P = 0.070 respectively). No patient in either group had vomiting. Seven patients in saline and zero patient in granisetron group had nausea that was statistically significant (P = 0.040). Time to discharge after surgery was 243 ± 21 and 239 ± 24
minutes in granisetron and control group respectively (P = 0.150).
Conclusions: Systemic granisetron had no effect on the duration of sensory and motor block produced by spinal anesthesia with hyperbaric bupivacaine.


Bupivacaine, Granisetron, Sensory block, Motor block, Anesthesia, Spinal, Outpatients, Cystoscopy

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