Complications, Indications and Results of Two Screening Methods: Amniocentesis and Chorionic Villus Sampling

Abstract

Background: Chorionic villus sampling (CVS) and amniocentesis are two invasive methods of diagnostic approaches for prenatal diagnosis. The indication, adverse effects and final outcome of these two methods are different. The goal of this study was to compare indication, complications and outcomes of CVS and amniocentesis in pregnant women underwent prenatal screening program.
Methods: Medical records of 1464 women who underwent CVS, or amniocentesis were reviewed in two tertiary hospitals (imam and women hospitals, affiliated hospitals of Tehran University of Medical Sciences).
Results: For 1073 patients amniocentesis was performed while for 391 cases CVS was one. Mean maternal age, gestational age, and age at birth of the neonates were significantly lower in CVS group than the other group. Mean needle time was significantly higher in CVS group. Mean needle time was significantly higher in CVS Group (1.3 vs. 1.5, P < 0.001). The most finding of CVS result was minor Thalassemia while trisomy 21 was the most finding in amniocentesis group. Rupture of membranes was the most side effects in amniocentesis group and intrauterine fetal death was the most complication in CVS group.
Conclusions: Indication, results and complications of CVS and amniocentesis are different.