Original Article

Investigating the relationship between the increase in color doppler ultrasound indices of the ophthalmic artery and the serum lactate level and the severity of the disease in patients with sepsis.

Abstract

Background: The objective of this study was to investigate the relationship between the increase in color
Doppler ultrasound indices of the ophthalmic artery and the serum lactate level and the severity of the disease in patients with sepsis.
Methods: This was a cross-sectional study conducted on 24 patients diagnosed with sepsis, who were admitted
to the intensive care unit of Shariati Hospital. The patients were more than 18 years old, hospitalized in the
first 42 hours, and selected by the portable color Doppler ultrasound available in the ICU department. The ESI
probe was placed on the patient’s eye with the eyelid closed, and the ophthalmic artery was located. The indices including RI, PSV, PI were measured along with their serum lactate levels. The correlation of these indices with the severity of sepsis was checked.
Results: In this study, 24 patients who were less than 81 years old were diagnosed with sepsis and had a sofa
score above 3. It was observed that there is a significant relationship between the dose of increased lactate levels
and PSV1, and this parameter can be considered a predictive factor. It was also observed that there is a significantrelationship between the dose of increased lactate levels and PSV2, and this parameter can be considered as am predictive factor. Additionally, there is a significant relationship between the dose of increased levels of lactateand PI, and this parameter can be considered as a predictive factor.
Conclusions: The study found a significant relationship between increased levels of lactate and decreased bloodsupply in the optic artery. It is suggested that due to the lack of numbers in this study, more samples should be investigated in future studies. In a scientific article, the use of “we” and “our” should be avoided. If necessary, the third person should be used.

1. de Oliveira CA, de Sá RA, Velarde LG, Monteiro VN, Netto HC. Doppler velocimetry of the ophthalmic artery: reproducibility of blood flow velocity measurements. J Ultrasound Med. 2012 Jun;31(6):879-84. https://doi. org/10.7863/jum.2012.31.6.879. PMID: 22644684.
2. Belfort MA, Saade GR. Retinal vasospasm associated with visual disturbance in preeclampsia: color flow Doppler findings. Am J Obstet Gynecol. 1993 Sep;169(3):523-5. https://doi.org/10.1016/0002- 9378(93)90612-m. PMID: 8372855.
3. Bill A. Blood circulation and fluid dynamics in the eye. Physiol Rev. 1975 Jul;55(3):383-417. https://doi. org/10.1152/physrev.1975.55.3.383. PMID: 1153528.
4. Abegão Pinto L, Vandewalle E, De Clerck E, Marques- Neves C, Stalmans I. Ophthalmic artery Doppler waveform changes associated with increased damage in glaucoma patients. Invest Ophthalmol Vis Sci. 2012 Apr 30;53(4):2448-53. https://doi.org/10.1167/iovs.11- 9388. PMID: 22427555.
5. Almeida-Freitas DB, Meira-Freitas D, Melo LA Jr, Paranhos A Jr, Iared W, Ajzen S. Color Doppler imaging of the ophthalmic artery in patients with chronic heart failure. Arq Bras Oftalmol. 2011 Sep-Oct;74(5):326-9. https://doi.org/10.1590/s0004-27492011000500003. PMID: 22183990.
6. Maruyoshi H, Kojima S, Kojima S, Nagayoshi Y, Horibata Y, Kaikita K, Sugiyama S, Ogawa H. Waveform of ophthalmic artery Doppler flow predicts the severity of systemic atherosclerosis. Circ J. 2010 Jun;74(6):1251-6. https://doi.org/10.1253/circj.cj-09- 0866. Epub 2010 Apr 10. PMID: 20410618.
7. Hradílek P, Stourac P, Bar M, Zapletalová O, Skoloudík D. Colour Doppler imaging evaluation of blood flow parameters in the ophthalmic artery in acute and chronic phases of optic neuritis in multiple sclerosis. Acta Ophthalmol. 2009 Feb;87(1):65-70. https://doi. org/10.1111/j.1755-3768.2008.01195.x. Epub 2008 Jun 19. PMID: 18616617.
8. de Souza MA, de Souza BM, Geber S. Vascular resistance of central retinal and ophthalmic arteries in postmenopausal women after use of tibolone. Menopause. 2012 Mar;19(3):328-31. https://doi. org/10.1097/gme.0b013e3182290b26. PMID: 22042323.
9. Aquino LO, Leite HV, Cabral AC, Brandão AH. Doppler flowmetry of ophthalmic arteries for prediction of pre-eclampsia. Rev Assoc Med Bras (1992). 2014 Nov-Dec;60(6):538-41. https://doi.org/10.1590/1806- 9282.60.06.011. PMID: 25650853.
10. Olatunji RB, Adekanmi AJ, Obajimi MO, Roberts OA, Ojo TO. Maternal ophthalmic artery Doppler velocimetry in pre-eclampsia in Southwestern Nigeria. Int J Womens Health. 2015 Jul 20;7:723-34. https://doi. org/10.2147/ijwh.s86314. PMID: 26229508; PMCID: PMC4514353.
11. Kalafat E, Laoreti A, Khalil A, Da Silva Costa F, Thilaganathan B. Ophthalmic artery Doppler for prediction of pre-eclampsia: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2018 Jun;51(6):731-737. doi: https://doi.org/10.1002/ uog.19002. Epub 2018 May 3. PMID: 29330892.
12. Onwudiegwu C, Adekanmi A, Olusanya B, Lawal O, Adedokun B, Morhason-Bello I, Oladokun A. Casecontrol study on ocular changes and ophthalmic Doppler velocimetric indices among preeclamptic andnormotensive pregnant women in Ibadan, Nigeria. BMJ Open Ophthalmol. 2020 Sep 13;5(1):e000550. https://doi.org/10.1136/bmjophth-2020-000550.PMID: 32984544; PMCID: PMC7488785.
13. Sarno M, Wright A, Vieira N, Sapantzoglou I, Charakida M, Nicolaides KH. Ophthalmic artery Doppler in prediction of pre-eclampsia at 35-37 weeks’ gestation. Ultrasound Obstet Gynecol. 2020 Nov;56(5):717- 724. https://doi.org/10.1002/uog.22184. Epub 2020 Oct 20. Erratum in: Ultrasound Obstet Gynecol. 2022 Mar;59(3):407. PMID: 32857890.
14. Sapantzoglou I, Wright A, Arozena MG, Campos RV, Charakida M, Nicolaides KH. Ophthalmic artery Doppler in combination with other biomarkers in prediction of pre-eclampsia at 19-23 weeks’ gestation. Ultrasound Obstet Gynecol. 2021 Jan;57(1):75-83. https://doi.org/10.1002/uog.23528. Epub 2020 Dec 4. Erratum in: Ultrasound Obstet Gynecol. 2022 Mar;59(3):407. PMID: 33142353.
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IssueVol 6 No 1 (2023) QRcode
SectionOriginal Article(s)
DOI https://doi.org/10.18502/ajs.v6i1.14716
Keywords
Septic shock – sepsis – lactate – optic nerve sheath diameter

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How to Cite
1.
mohammadiafrakoti nima, marashi seyyed mojtaba, saeidi shabnam, talebikahdouei mohammadsadegh, aghaei fatemeh. Investigating the relationship between the increase in color doppler ultrasound indices of the ophthalmic artery and the serum lactate level and the severity of the disease in patients with sepsis. AJS. 2023;6(1):34-37.